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The treatment of various skin diseases is carried out thanks to drugs containing isotretinoin. The substance is classified as dermatoprotective due to its unique properties. The drug with the same name is used to treat seborrhea, acne. "Isotretinoin" instructions for use recommend using only after consulting a doctor. According to reviews, the remedy is effective in inflammatory processes on the skin.
Tool description
The drug "Isotretinoin" is a powerful retinoid. The latter refers to derivatives of vitamin A. The active substance itself - isotretinoin - is known as and has the form of a yellowish powder. The substance is able to neutralize rapidly dividing cancer cells. This property was originally used for the treatment of oncological pathologies.
After some time, scientists discovered another healing property of the powdered substance - it can reduce the production of sebum by suppressing the excessive growth of the cell epithelium of the excretory ducts. It is this property that currently allows the use of Isotretinoin for the treatment of severe acne.
Preparations based on this active ingredient can be used both externally and orally. The optimal remedy is selected by a dermatologist after examining the patient.
How does the medicine work?
The drug "Isotretinoin" instructions for use recommends using for the effective treatment of acne rashes and other skin diseases. The therapeutic effect of the drug affects immediately all the factors that provoke these ailments. First of all, the production of sebum decreases, the pores are cleared.
Systemic retinoid prevents the growth of pathological microorganisms Propionibacterium acnes, which cause acne, pimples. The relief of the inflammatory process, the normalization of the pH level is also the merit of the drug. Isoteretinoin is actively used in dermatology and cosmetology. The active component allows you to influence not only the symptoms of the disease, but also eliminate the cause that led to the development of the inflammatory process.
Indications for appointment
It should be borne in mind that without the prior appointment of a doctor, it is not recommended to use Isotretinoin. The price of drugs for external use based on the active substance of the same name ranges from 280-650 rubles. The drug is prescribed in the form of tablets in the presence of certain pathologies. It:
- seborrhea;
- rosacea (including severe forms);
- all forms of acne;
- nodular cystic acne;
- various types of dermatitis;
- congenital ichthyosis.
Most of these ailments are united by the cause of origin - excessive work of the sebaceous glands. This, in turn, leads to a serious disruption of the normal balance of the epidermis.
What effect will the remedy have?
According to numerous studies, the effectiveness of the drug in a variety of skin diseases has been confirmed. "Isotretinoin" significantly reduces the activity of the sebaceous glands (by 90%) and normalizes the processes occurring in the skin. Doctors recommend using the drug in the form of Roaccutane tablets even in severe acne. Isotretinoin is used as the main active ingredient.
Means for external application have proven themselves well for rosacea and dermatitis. Such retinoids can be used for mild to moderate skin diseases. Experts say that the drug in this form is much safer for the body than capsules. With oral administration of isotretinoin, its concentration in the blood increases to 2000 ng / ml. If you use an ointment, this figure will not exceed 60 ng / ml.
Isotretinoin-based drugs
The active substance isotretinoin, instructions for use, refers to natural retinoids. In a small amount, these compounds are well absorbed by the body, have a positive effect on the condition of the skin, reduce the production of sebum, and have an antimicrobial effect. Some topical preparations contain isotretinoin:
- "Isotrexin" (gel).
- "Retasol" (solution).
For oral use in severe pathologies of the skin, experts prescribe medications such as Aknekutan, Roakkutan, Erase. Composition (isotretinoin is used as the active substance) and dosage may vary.
Side effects
When the dosage is exceeded, isotretinoin causes side effects. From the side of the immune system, they appear most often. Patients complain of rashes, redness, peeling of the skin on the palms and soles of the feet, itching, degeneration of the nail plates. It is also possible the appearance of cheilitis - a disease that affects the skin on the lips.
The nervous system in some patients also suffers due to treatment with Isotretinoin. Reviews indicate that a headache, excessive fatigue may appear, visual acuity is impaired, depression and psychosis develop. It is extremely dangerous for people with a history of bronchial asthma to take the drug. This can lead to bronchospasm. Side effects on the organs of vision are manifested by symptoms such as keratitis, blepharitis, conjunctivitis, eye irritation.
On the part of the digestive tract, pancreatitis, diarrhea, internal bleeding, vomiting, inflammation of the intestinal mucosa, and hepatitis develop. Arthritis, joint and muscle pain, hyperostosis are symptoms of the negative effects of isotretinoin on the musculoskeletal system.
Contraindications
First of all, the drug "Isotretinoin" instructions for use prohibits taking during pregnancy or its planning. The substance is embryotoxic and can lead to developmental anomalies and birth defects in the fetus. Also, experts recommend starting planning a pregnancy no earlier than 3-4 months after the end of drug treatment. During this time, the level of isotretinoin in the body should return to normal.
It is forbidden to take any retinoids during lactation, with hypersensitivity or intolerance, combine the drug with tetracycline antibiotics. Oral medication is contraindicated in case of severe impairment of the liver and kidneys, with an increased value of lipids in the blood serum and malignant tumors. Isotretinoin is also not suitable for patients with hypervitaminosis A.
The price of the cheapest product based on this substance is 280-350 rubles. The treatment regimen, dosage, analogues are selected exclusively by the attending physician.
How to take?
Isotretinoin oral capsules should be taken with meals. The initial dosage usually does not exceed 0.1 mg per kilogram of the patient's body weight. In the future, the dose can be increased (in the case of positive dynamics and the absence of side effects).
The average daily dosage (0.5 g) should be divided into several doses. Depending on the severity of the disease, it can be increased. It should be borne in mind that no more than 10 g of isotretinoin can be taken per day. Treatment with the drug is usually long, 16-24 weeks. The interval between courses of therapy should be at least two months.
The drug "Roaccutane"
The price of the drug is quite high and is about 2700 rubles per pack (dosage 20 mg). The manufacturer is the Swiss pharmaceutical company "Hoffman la Roche". Roaccutane capsules are effective for severe acne vulgaris, ichthyosis, keratoderma.
The duration of therapy depends on the type of disease and is usually 2-4 weeks. Per day, 0.5 mg of the active substance per 1 kg of the patient's weight should be taken. With normal tolerability of Roaccutane, a second stage of therapy should begin, the duration of which is approximately 20 weeks. In this case, the doctor must monitor the dynamics of the pathology. If there is a decrease in rashes by 70-80%, the drug is usually canceled.
Application features
During the period of treatment with Roaccutane, an exacerbation of the disease is possible. In this case, it is necessary to reduce the dose of the drug to the minimum (0.5 mg / kg). Usually, positive dynamics and a stable result of therapy can be observed 1.5-2 months after the start of treatment. However, in severe cases, a longer course of taking Roaccutane will be required.
The price of a drug based on isotretinoin depends on the dosage of the active ingredient. Capsules may contain 10 or 20 mg of this substance. Subject to the dosage and treatment regimen, the drug should not cause side effects. Reviews of experts suggest that "Roaccutane" is well tolerated by patients.
Solution "Retasol"
The active ingredient of the drug is isotretinoin. Reviews of patients and dermatologists confirm the therapeutic efficacy of this medication. The active substance in the preparation contains 0.025 mg per 1 ml. The solution, in addition to the anti-inflammatory and regenerating effect, has a positive effect on the relief of the skin. The drug is intended for application to previously cleansed skin. The procedure should be repeated twice a day. The duration of treatment with Retasol is usually 4-12 weeks.
Do not use the solution in combination with other retinoids. This can provoke the development of hypervitaminosis A. Do not prescribe "Retasol" in the treatment of tetracyclines because of the risk of increased intracranial pressure.
In the form of a solution, the drug can be used to treat acne in adolescents from 11 years of age. The tool has passed clinical trials, during which its safety has been proven. "Retasol" is an ideal remedy for oily skin.
Retinoids- these are not some kind of gels, ointments, creams, etc. Retinoids are called special active ingredients / substances in various preparations, both local or external (lotions, gels, creams, etc.) and systemic, i.e. taken orally in tablets / capsules (roaccutane, roa, etc.). This review only covers topical or topical products (lotions, gels, creams, etc.)
For example, the most famous topical/topical preparation or, more simply, Retin-A cream contains the active ingredient, a retinoid called Tretinoin (Tretinoin). Another well-known topical/topical preparation or, more simply, Differin gel contains an active ingredient, a retinoid called Adapalene (Adapalene). The name of the active ingredient/substance in a particular product is usually (almost always) listed under the name of the drug itself - so you can easily determine it yourself.
Retinoids are perhaps the most mysterious and powerful chemical compounds that, due to their properties, namely, the presence of unique receptors, can affect absolutely all layers of the skin in the widest possible way. They act in only one way - they help our skin to live, be healthy and cope with daily problems, while remaining beautiful, supple, “vigorous” and aesthetically attractive! For those not in the know, retinoids are derived from Vitamin A and mostly synthetically.
It is necessary to make a reservation additionally on the use - you must be able to use retinoids, but do not abuse them! Only then will the best result be achieved.
Retinoids for me, the most beloved and significant event - a certain period in life, which divides the treatment itself into "before" and "after"! Why period? Because it doesn’t “come” right away - it takes everyone some time. If we talk specifically about the moment, then it will be Benzoyl Peroxide PB (Benzoyl peroxide), because. it does not take much time to understand its effectiveness (literally days or even days).
Among more than 5,000 retinoids, only a few are the most effective and safe.
An old-timer and at the same time, one of the most effective, of course, is retinoids called Tretinoin (Tretinoin) and Isotretinoin (Isotretinoin) - they are closest in structure to Vitamin A.
Why are retinoids needed?
There are probably no indicators that retinoids do not affect in a positive way. All this, in the end, is expressed in an aesthetic form - the skin is healthier and looks better, i.e. beautiful, aesthetically pleasing to the eye:
Acne - actively fighting problem skin
Color - improves skin color
Texture and density (flabbiness) - improves and enhances the overall condition of the skin surface
Wrinkles - shrink with long periods of use - at least six months or several years, it all depends on the situation
"Fatigue" - decreases with the correct and regular use of retinoids and parallel peeling
Retinoids are a very powerful weapon and therefore, with the wrong approach, alas, the skin can react with side effects and can even be damaged.
Retinoids and side effects
Very often, if a person is in a hurry or does not understand how to correctly combine different means, tools, he does not know what is what, i.e. interferes with "everything in a bunch" problems arise. Common problems with this:
irritability
redness
dryness and tightness
peeling
itching and pain
Acne treatment and retinoids.
The meaning of the application and treatment regimen
The whole treatment regimen for problem skin, or rather the correct and effective (complete) acne treatment regimen, is based on 2 points. Just two questions that need to be addressed in order to get rid of acne and problem skin in general:
inflammation, i.e. to overcome all inflammatory reactions in the skin, and even better - to warn / prevent them in advance. Success in this matter is the complete absence of pus and the result of this is that there will be not a single element on the skin, with the exception of non-inflammatory small elements, which can also be eliminated (see paragraph 2)
hyperkeratosis - excessive thickening of the top layer of the skin or an abnormal accumulation of dead cells on the surface of the skin. These layers are not visible if you look at the skin, because. these are microlayers, i.e. much less than a millimeter thick. But these accumulations of dead cells ultimately play a key role in skin health and aesthetic appearance. It is the use of exfoliants (i.e. special substances that actively cleanse the surface of the skin) that will help to cope with the second problem/question.
Retinoids are very powerful exfoliants with an additional(!) anti-inflammatory effect.
Simply put, if you get rid of the multi-layered, superfluous accumulation of dead cells on the surface of the skin, then acne and problem skin, in general, will disappear by half. And the rest, the first half, is the first point, i.e. inflammation. I repeat that substances that can actively exfoliate excess from the surface of the skin are called exfoliants, and the process of their action (exfoliation) is called exfoliation or peeling (eng. Peel - exfoliation).
So, if we fight in the best way with item 1. inflammation and with item 2. hyperkeratosis, then we will get rid of problem skin.
This is the full truth and the whole essence of any treatment that exists at the moment all over the world. You can treat from the inside, or you can treat from the outside - but the best thing is at the same time: external treatment + internal treatment - this is the shortest and most reliable way, which guarantees a 100% result.
It remains only to understand what are the best ways / tools to combat inflammation and hyperkeratosis! Now I will not list everything and everything, but I will single out only retinoids.
These are chemically active substances derived from vitamin A, with special receptors, due to which they simultaneously have both powerful exfoliating (exfoliating) and anti-inflammatory properties. In other words, retinoids simultaneously fight against item 1. inflammation and p.2. hyperkeratosis, and they are very powerful and therefore effective.
Retinoids - what are they and how to use them?
There are more than 5,000 different types of retinoids. The more a retinoid differs from Vitamin A, the larger its generation. The best/effective and common retinodes for acne treatment are the 1st generation retinoids: Tretinoin and Isotretinoin. Adapalene and Tazarotene are 4th generation retinoids also used to treat acne.
Any topical (external, i.e. applied to the skin) retinoid for acne treatment is used in minimal amounts and only in the evening. All the conditions and nuances of its use are due to the fact that retinoids are very powerful / active substances and therefore, like all powerful weapons, they must be handled with extreme care. Therefore, if we apply in the morning (for the day), then our skin will not withstand such exposure due to the influence of the Sun's rays during the day. At night it is “dark” and the skin is not so loaded and can withstand, i.e. the risk of side effects is minimal.
The same principle applies to the amount of retinoid applied to the skin - the more we apply at a time, the more we load our skin. Therefore, it is necessary to observe the principle: “it is necessary and sufficient” in order to “not overdo it” - in practice, in most cases, the smallest doses in the evening. This is especially true for beginners, and you will be a beginner within 3-6 months of using retinoids. The fact is that the skin gets used to retinoids for a very long time, regardless of how it tolerates them - complete addiction takes from 3-6 months to 1 year.
Depending on the circumstances and places of application, the concentration of retinoids in various preparations varies from 0.01% to 0.1%. The most common in terms of efficiency is 0.05%.
You also need to know (since retinoids are very active) that retinoids are subject to degradation or deactivation, i.e. interacting with various active components, they lose their properties. For example, the retinoid Tretinoin is NOT compatible with Benzoyl peroxide or, for example, retinoids are NOT compatible with AHA-BHA. In practice, this means that retinoids and AHA-BHA should not be applied to the skin at the same time. But it is possible (and necessary for a powerful / effective treatment) to spread the application, for example, Benzoyl peroxide PB (Benzoyl peroxide) - in the morning, retinoid / tretinoin - in the evening, etc.
Also, you need to remember that busting with the dosage can lead to side effects. So, for example, the retinoid Adapalene (Adapalene) is compatible with Benzoyl Peroxide PB (Benzoyl peroxide) and can be applied to each other (there is even a special drug Effezel) - but you can overdo it with dosages and this can lead to side effects.
So, to summarize - try to apply very little, on all zones and only in the evening before bedtime. The best retinoid is Tretinoin, Retin-A cream 0.05%. The best concentration in most cases is 0.05%, because. it's not too much and not too little. Do not apply retinoids at the same time with anything at all - moisturizing is NOT needed in most cases. There are cases when moisturizing is applied or something else “before”, but this is a separate conversation. Lotion (tonic) before retinoids is better not to apply, because. it will spoil (due to the high activity of retinoids to deactivate) rather than be useful. Lotion (tonic) is NOT a necessity, it is just an addition in some cases, because. for effective treatment, it is completely optional. Another conclusion - in the evening it is better to use a simple (without active components), normal, soft and liquid wash, because. retinoids can lose their properties (more often) or there will be side effects on the face (less often) if, for example, the cleanser is hard.
Let's compare Retinoids and other "mazyukalki"?
I'll tell you one thing that "in a good way" should be said to everyone and then often reminded. Here you see different ointments, creams, gels, etc. everywhere. There are a lot of them, there are 100-200 different types of drugs with retinoids, different companies, concentrations, forms, etc. There are other different drugs with other active ingredients, which are many times more. Imagine such a specialized pharmacy for a person with problem skin, which would sell all the products for us - in terms of area it would be like several large stadiums - and several floors.
- Have you imagined?
Lots of funds?
- Not the right word, just the sea!
So among such a huge number there will always be the best means that are more effective than others and that really give results. After all, there is always better and worse. So, among all, all the remedies for the treatment of problem skin are the same, the most are the remedies with retinoids, and the best drug with retinoids is Retin-A 0.05% cream. For those who for some reason cannot use retinoids, there are AHA-BHA acids. AHA-BHA can be called an analogue of retinoids with a similar spectrum of action and effectiveness - these are also the very best remedies among many, many others.
Interview! Please try not to rush - your opinion is very important!
So, external or local preparations (emulsions, gels, creams, etc.) with retinoids:
Tretinoin (Tretinoin)
Isotretinoin (Isotretinoin)
Adapalene (Adapalene)
Tazarotene (Tazarotene)
1. Tretinoin (Tretinoin)
Name: Retin-A
Release form of the drug: cream
Title: Obagi
Release form of the drug: cream
Active ingredient: Tretinoin (Tretinoin)
Title: Renova
Release form of the drug: cream
Active ingredient: Tretinoin (Tretinoin)
Name: Retino-A
Release form of the drug: cream
Active ingredient: Tretinoin (Tretinoin)
Name: Stieva-A
Release form of the drug: cream
Active ingredient: Tretinoin (Tretinoin)
Name: Tretinoin creams
Release form of the drug: cream
Active ingredient: Tretinoin (Tretinoin)
Name: Tretinoin gel lotion
Release form of the drug: gel, lotion
Active ingredient: Tretinoin (Tretinoin)
Title: Airol
Release form of the drug: cream, lotion
Active ingredient: Tretinoin (Tretinoin)
Title: Locacid
Release form of the drug: cream
Active ingredient: Tretinoin (Tretinoin)
Title: Ziana
Release form of the drug: gel
Active ingredient: Tretinoin (Tretinoin) + Clindamycin (Clindamycin)
Retinoid products called
2. Isotretinoin (Isotretinoin)
Name: Isotrex
Release form of the drug: gel
Name: Isotrexin
Release form of the drug: gel
Active ingredient: Isotretinoin (Isotretinoin)
Name: Isotrexin
Release form of the drug: cream
Active ingredient: Isotretinoin (Isotretinoin)
Name: Retasol
Release form of the drug: lotion
Active ingredient: Isotretinoin (Isotretinoin)
Name: Retinoic ointment
Release form of the drug: ointment
Active ingredient: Isotretinoin (Isotretinoin)
Retinoid products called
3. Adapalene
Name: Adaklin, Adaclean
Release form of the drug: cream
Title: Adaclene
Release form of the drug: gel
Active ingredient: Adapalene (Adapalene)
Title: Adapaleno
Release form of the drug: cream
Active ingredient: Adapalene (Adapalene)
Title: Epiduo
Release form of the drug: gel
Active ingredient: Adapalene (Adapalene)
Title: Adolene
Release form of the drug: gel
Active ingredient: Adapalene (Adapalene)
Title: Bezugrey
Release form of the drug: gel
Active ingredient: Adapalene (Adapalene)
Name: Deriva, Deriva-S
Release form of the drug: gel
Title: Differin
Release form of the drug: gel
Active ingredient: Adapalene (Adapalene)
Name: Klenzit, Klenzit-S
Release form of the drug: gel
Active ingredient: Adapalene (Adapalene) (+ Clindamycin (Clindamycin))
Title: Effezel
Release form of the drug: gel
Active ingredient: Adapalene (Adapalene) + Benzoyl peroxide (Benzoyl peroxide)
Retinoid products called
4. Tazarotene
Title: Tazorac
Release form of the drug: gel
Title: Zorak
Release form of the drug: gel
Active ingredient: Tazarotene (tazaroten)
The content of all-trans retinoic acid in food is relatively low (in contrast to the content of retinol), and there are no special mechanisms for its absorption, transport in plasma and storage in tissues. After absorption, all-trans retinoic acid circulates in plasma in complex with albumin. Quantitative studies of its absorption in the gastrointestinal tract in humans have not been conducted. There is a drug of all-trans retinoic acid - tretinoin. When applied to the skin, approximately 5% of the total dose (together with metabolites) is found in the urine; systemic side effects with this method of application are not expressed. However, attempts to treat dermatoses by oral tretinoin may cause severe hypervitaminosis A.
Tretinoin is rapidly metabolized in the liver; its various conjugates and decay products enter the bile and are excreted in the urine and feces. From tretinoin, 13-cns-retinoic acid (isotretinoin), conjugates with glucuronic acid and taurine are formed; in addition, tretinoin is oxidized at position 4 of the p-ionone ring (Allen and Bloxham in Symposium, 1989b). Tretinoin has been used to stimulate leukemia cell differentiation in acute promyelocytic leukemia. However, the remission turned out to be short-lived due to the pharmacokinetic properties of the drug - with prolonged use, the maximum serum concentration of tretinoin progressively decreases (see below). Another isomer, 9-cis-retinoic acid, activates receptors in the same family as tretinoin and therefore has the same medicinal properties. Differences in the pharmacokinetic properties of 9-cis-retinoic acid and tretinoin, revealed in experiments on nude mice, allow us to hope for its greater effectiveness in acute promyelocytic leukemia (Achkar et al., 1994).
Isotretinoin
After taking isotretinoin (13-cis-retinoic acid) orally, its serum concentration reaches a maximum after 2-4 hours. The bioavailability of isotretinoin when taken on an empty stomach is approximately 20%; when taken with food, the absorption of the drug increases significantly. Isotretinoin has no local effect. In plasma, the drug actively binds to albumin, and the concentration of isotretinoin in the blood is usually higher than in the tissues.
Isotretinoin in the body is reversibly converted to tretinoin, and approximately 20-30% of the administered isotretinoin is metabolized in this way. With repeated administration of the drug, its main metabolite, 4-oxoisotretinoin, accumulates in the blood. Metabolites and the parent substance (in the form of conjugates with glucuronic acid) are excreted into the bile. T1 / 2 of isotretinoin is 6-36 hours. With repeated administration, stationary serum concentration is reached after 5-7 days. Some metabolites of isotretinoin disappear from plasma rather slowly. Because of the possible teratogenic effects of retinoids, women are advised to avoid pregnancy for at least 1 month after stopping their use. The pharmacokinetics of isotretinoin are reviewed by Allen and Bloxham in Symposium, 1989b.
Retinol is one of the main ingredients in skin care products. Cosmetics containing such an ingredient are designed to combat premature wrinkles and acne.
However, the concepts of what retinol and retinoid are are often confused. Let's take a look at what these names mean, what is their difference, and how they can help, being in cosmetic preparations.
Retinol what is it. Definition
Retinol is the scientific name for the chemical component of Vitamin A. It is he who is the "pure" type of such an organic compound.
In our body, vitamin A is produced by splitting from foods containing beta-carotene. After passing through the intestinal tract, it is stored in the liver in the form of retinol derivatives.
Vitamin A cannot be stored in its pure form, and is often destroyed by external factors. However, it dissolves well in fat, acquiring a special structure, while maintaining its properties. That is why it is so loved to be added to cosmetics for external use, where it so easily penetrates the skin.
Retinoids are called special chemical formations derived from Retinol. They include many substances that are similar in composition and have the same element - vitamin A.
Features of retinol when exposed to the skin
The peculiarity of such a substance is that it acts on the skin from the inside. And thanks to its ability to dissolve in fatty components, it starts to activate the cells of the inner layer of the skin, saturating them with itself. From such nutrition, cells begin to work in an accelerated mode, producing new ones and restoring old ones.
It is thanks to this feature that Vitamin A helps in the fight against many skin problems. However, in order to achieve a visible result, it is necessary to use retinol components of cosmetic preparations for a long time.
Notice! In some cases, when retinol acts on the skin, nourishing the cells, peeling may begin. Because of this, many people begin to perceive cosmetics with retinol as exfoliating. In fact, Vitamin A is not, and cannot be a purifier. Peeling of the skin occurs because dead cells fall off, letting new ones into their place.
Isotretinoin and tretinoin differences
Retinol derivatives, and more specifically Retinoids, have only two types of classification.
natural retinoids.
This type of vitamin A is produced by the body itself. Some of them have names like palmates, aldehydes, or complex combinations like tretinoin. Most often they can be contained in cosmetics, skin care products.
synthetic retinoids.
This chemical product is already grown in laboratories. Thanks to this "birth", their molecular component is already significantly different from natural origin, but has the same properties. Therefore, their names have the endings "en" and in some cases the prefix "iso" (isotretinoin). Such components are already contained in preparations for direct treatment.
Distinctive features.
1 . Interaction with cellular receptors.
Vitamin A, which has a natural form, works better with cells, forcing them to carry out “commands” at full capacity. When it enters the body in the form of Tretinoin, it is broken down to its simplest form. And after that, all cellular receptors begin to work at full capacity.
Artificial retinoids can only make certain receptors work. That is why they are also called dotted. That is, they work in the same direction.
2 . Isolation of unpleasant consequences of the skin.
Since the interaction on cells in these types of "retinol components" is different, therefore, the skin will be restored at different speeds and directions.
While tretinoids act on all cellular receptors, its commands may not be enough for a long time. Therefore, the skin is so slowly restored. But due to the small concentration in cosmetic preparations, it is practically harmless, and they cannot cause an overdose.
However, isotretinoins, acting in a "point" direction, cope with the restoration of the skin cover faster. Therefore, they are added to preparations for emergency treatment of damaged and problematic areas of the skin, such as eczema or dermatitis.
It should be noted that drugs containing synthetic retinol may not always be safe to use. Its concentration is much higher than can be contained in cosmetics, so its use is prescribed by a dermatologist, indicating the desired dosage.
impact resistance.
*Natural retinoids are not stable. When exposed to external environmental factors, an oxidizing process occurs, after which they carry a toxic character. In order to protect yourself, drugs that contain such a component are best used in the dark.
* Synthetic retinoids are no longer destroyed by sunlight. However, in order to avoid side effects after application, it is advisable to apply a protective cream.
Retinoids in cosmetology
Since there are a lot of retinol shaped in our world, we will consider sewing those types of Vitamin A that are used in skin care products, and some professional preparations that are available without a doctor's prescription.
In cosmetics
Retinol
Retinol or retinyl palmates
Retinyl and retinol acetates
Retinal aldehydes
In serious drugs
Tretinoin(trans - retinoic - acid) - used in anti-wrinkle products
Isotretinoin- used in ointments against acne, such as Retinoic.
Adapalene is an active ingredient in anti-acne preparations.
Tazatoren- can be used both to combat skin aging and teenage rash.
Differences in application.
We have already found out that tretinoin is the fastest form of Vitamin A. That is, skin cells are more sensitive to it.
Therefore, in order for the remaining forms of retinol to have the same effect on the skin as retinoic acid, they need to go through the process of splitting and combining, becoming tretinoin.
Many drugs that are taken strictly under the prescription of doctors may contain natural retinoic acid. However, even if the cellular receptors are supplied with a ready-made form of retinol for nutrition, the risk of side effects cannot be avoided. That is why drugs containing such retinol should be taken with caution and under the supervision of doctors.
Cosmetic vitamin A has a much milder effect on cellular organisms. That is why there are practically no side effects from the use. But it is worth considering the fact that the visible effects of exposure will appear much longer.
Retinol, which is found in cosmetic skin care products, comes in different forms. They can differ both in the initial structure and in the speed of impact. Although the end result is the same for everyone, they need to go through their life path differently, turning into retinoic acid.
Transformation of retinoids in the body.
We have already found out that before starting to "work", our vitamin must go through a series of splits and formations in order to become tretinoin.
Natural retinoids, unlike artificial ones, go through a long transformation before becoming the right ingredient. Therefore, it will be considered weak in impact.
For example, in order to eventually become tretinoin, retinol palmate must first become retinol, and then, after converting to retinal aldehyde, and ultimately becoming an acid.
Start using retinol with a cosmetic line of products. After all, not all drugs that contain a fast form of the vitamin are harmless. That is why they are released only by prescription. Many carry a number of side effects. Consider first whether you should take such drugs unnecessarily.
Let's summarize...
Retinol is made from beta-carotene and goes through a complex process in our body.
It is the chemical name for Vitamin A.
Retinoids is a general classifier of the Vitamin A family, the common progenitor of which is Retinol.
The main beauty of retinoids is that they act on our skin deeply at the cellular level, giving certain signals, as a result of which even the most significant problems of skin diseases disappear.
They can be both natural and artificial. The former are produced by the body itself, while the latter are grown in laboratories.
Natural retinoids, used in skin care cosmetics, are weaker in effect. However, they cannot cause harm and have no side effects.
Synthetic retinoids are found in more serious drugs that are available only by prescription. And although their effect on skin cells is faster, they have side effects.
Before taking products containing retinol, consult a specialist to choose the right dosage of the drug and protect yourself from side effects.
